Regulation of the immune tolerance system determines the susceptibility to HLA-mediated abacavir-induced skin toxicity
Abstract
Idiosyncratic drug toxicity (IDT) associated with specific human leukocyte antigen (HLA) allotype is a rare and unpredictable life-threatening adverse drug reaction for which prospective mechanistic studies in humans are difficult. Here, we show the importance of immune tolerance for IDT onset and determine whether it is susceptible to a common IDT, HLA-B*57:01-mediated abacavir (ABC)-induced hypersensitivity (AHS), using CD4+ T cell-depleted...
Paper Details
Title
Regulation of the immune tolerance system determines the susceptibility to HLA-mediated abacavir-induced skin toxicity
Published Date
Sep 28, 2021
Journal
Volume
4
Issue
1
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