Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality.

Background null There is considerable variability in COVID-19 outcomes amongst younger adults-and some of this variation may be due to genetic predisposition. null Methods null We combined individual level data from 13,888 COVID-19 patients (N=7,185 hospitalized) from 17 cohorts in nine countries to assess the association of the major common COVID-19 genetic risk factor (chromosome 3 locus tagged by rs10490770) with mortality, COVID-19-related...