Genetic Stratification of Age‐Dependent Parkinson's Disease Risk by Polygenic Hazard Score
Abstract
Parkinson's disease (PD) is a highly age-related disorder, where common genetic risk variants affect both disease risk and age at onset. A statistical approach that integrates these effects across all common variants may be clinically useful for individual risk stratification. A polygenic hazard score methodology, leveraging a time-to-event framework, has recently been successfully applied in other age-related disorders.We aimed to develop and...
Paper Details
Title
Genetic Stratification of Age‐Dependent Parkinson's Disease Risk by Polygenic Hazard Score
Published Date
Oct 6, 2021
Journal
Volume
37
Issue
1
Pages
62 - 69
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