Characteristic attributes limiting the transport rates in NCX orthologs
Volume: 1864, Issue: 1, Pages: 183792 - 183792
Published: Feb 1, 2022
Abstract
The Na+/Ca2+ exchangers (NCXs) modulate the Ca2+ signaling and homeostasis in health and disease. The transport cycle turnover rates (kcat) and the kcat/Km values of eukaryotic NCXs are ~104-times higher than those of prokaryotic NCXs. Three ion-coordinating residues (out of twelve) differ between eukaryotic NCXs and NCX_Mj. The replacement of three ion-coordinating residues in NCX_Mj does not increase kcat, probably due to the structural...
Paper Details
Title
Characteristic attributes limiting the transport rates in NCX orthologs
Published Date
Feb 1, 2022
Volume
1864
Issue
1
Pages
183792 - 183792
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