Assessment of dermal bioavailability: predicting the input function for topical glucocorticoids using stratum corneum sampling
Volume: 12, Issue: 4, Pages: 851 - 861
Published: Oct 1, 2021
Abstract
Predicting the dermal bioavailability of topically delivered drugs is challenging. In this work, minimally invasive stratum corneum (SC) sampling was used to quantify the delivery of betamethasone valerate (BMV) into the viable skin. Betnovate® cream (0.1% w/w BMV) was applied at three doses (2, 5, and 10 mg cm-2) to the ventral forearms of 12 healthy volunteers. The mass of drug in the SC was measured using a validated tape-stripping method (a)...
Paper Details
Title
Assessment of dermal bioavailability: predicting the input function for topical glucocorticoids using stratum corneum sampling
Published Date
Oct 1, 2021
Volume
12
Issue
4
Pages
851 - 861
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