Modulation of fracture healing by the transient accumulation of senescent cells

eLife7.70
Volume: 10
Published: Oct 7, 2021
Abstract
Senescent cells have detrimental effects across tissues with aging but may have beneficial effects on tissue repair, specifically on skin wound healing. However, the potential role of senescent cells in fracture healing has not been defined. Here, we performed an in silico analysis of public mRNAseq data and found that senescence and senescence-associated secretory phenotype (SASP) markers increased during fracture healing. We next directly...
Paper Details
Title
Modulation of fracture healing by the transient accumulation of senescent cells
Published Date
Oct 7, 2021
Journal
Volume
10
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