Pharmacological inhibition of Mint3 attenuates tumour growth, metastasis, and endotoxic shock
Abstract
Hypoxia-inducible factor-1 (HIF-1) plays essential roles in human diseases, though its central role in oxygen homoeostasis hinders the development of direct HIF-1-targeted pharmacological approaches. Here, we surveyed small-molecule compounds that efficiently inhibit the transcriptional activity of HIF-1 without affecting body homoeostasis. We focused on Mint3, which activates HIF-1 transcriptional activity in limited types of cells, such as...
Paper Details
Title
Pharmacological inhibition of Mint3 attenuates tumour growth, metastasis, and endotoxic shock
Published Date
Oct 7, 2021
Journal
Volume
4
Issue
1
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