Rheb-regulated mitochondrial pyruvate metabolism of Schwann cells linked to axon stability
Abstract
The metabolic coupling of Schwann cells (SCs) and peripheral axons is poorly understood. Few molecules in SCs are known to regulate axon stability. Using SC-specific Rheb knockout mice, we demonstrate that Rheb-regulated mitochondrial pyruvate metabolism is critical for SC-mediated non-cell-autonomous regulation of peripheral axon stability. Rheb knockout suppresses pyruvate dehydrogenase (PDH) activity (independently of mTORC1) and shifts...
Paper Details
Title
Rheb-regulated mitochondrial pyruvate metabolism of Schwann cells linked to axon stability
Published Date
Nov 1, 2021
Journal
Volume
56
Issue
21
Pages
2980 - 2994.e6
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