APOE4 genotype exacerbates the depression-like behavior of mice during aging through ATP decline
Abstract
Population-based studies reveal that apolipoprotein E (APOE) ε4 gene allele is closely associated with late-life depression (LLD). However, its exact role and underlying mechanism remain obscure. The current study found that aged apoE4-targeted replacement (TR) mice displayed obvious depression-like behavior when compared with age-matched apoE3-TR mice. Furthermore, apoE4 increased stress-induced depression-like behaviors, accompanied by...
Paper Details
Title
APOE4 genotype exacerbates the depression-like behavior of mice during aging through ATP decline
Published Date
Oct 5, 2021
Journal
Volume
11
Issue
1
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