RAS induced senescence of skin keratinocytes is mediated through Rho‐associated protein kinase (ROCK)
Abstract
Cellular senescence is a well-documented response to oncogene activation in many tissues. Multiple pathways are invoked to achieve senescence indicating its importance to counteract the transforming activities of oncogenic stimulation. We now report that the Rho-associated protein kinase (ROCK) signaling pathway is a critical regulator of oncogene-induced senescence in skin carcinogenesis. Transformation of mouse keratinocytes with oncogenic RAS...
Paper Details
Title
RAS induced senescence of skin keratinocytes is mediated through Rho‐associated protein kinase (ROCK)
Published Date
Sep 17, 2021
Journal
Volume
60
Issue
12
Pages
799 - 812
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