Vertex-wise multivariate genome-wide association study identifies 780 unique genetic loci associated with cortical morphology
Abstract
Brain morphology has been shown to be highly heritable, yet only a small portion of the heritability is explained by the genetic variants discovered so far. Here we extended the Multivariate Omnibus Statistical Test (MOSTest) and applied it to genome-wide association studies (GWAS) of vertex-wise structural magnetic resonance imaging (MRI) cortical measures from N=35,657 participants in the UK Biobank. We identified 695 loci for cortical surface...
Paper Details
Title
Vertex-wise multivariate genome-wide association study identifies 780 unique genetic loci associated with cortical morphology
Published Date
Dec 1, 2021
Journal
Volume
244
Pages
118603 - 118603
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