Systematic functional characterization of antisense eRNA of protocadherin α composite enhancer
Abstract
Enhancers generate bidirectional noncoding enhancer RNAs (eRNAs) that may regulate gene expression. At present, the eRNA function remains enigmatic. Here, we report a 5' capped antisense eRNA PEARL (Pcdh eRNA associated with R-loop formation) that is transcribed from the protocadherin (Pcdh) α HS5-1 enhancer region. Through loss- and gain-of-function experiments with CRISPR/Cas9 DNA fragment editing, CRISPRi, and CRISPRa, as well as locked...
Paper Details
Title
Systematic functional characterization of antisense eRNA of protocadherin α composite enhancer
Published Date
Sep 16, 2021
Journal
Volume
35
Issue
19-20
Pages
1383 - 1394
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