Pharmacologic approaches to amino acid depletion for cancer therapy

Volume: 61, Issue: 2, Pages: 127 - 152
Published: Sep 17, 2021
Abstract
Cancer cells undergo metabolic reprogramming to support increased demands in bioenergetics and biosynthesis and to maintain reactive oxygen species at optimum levels. As metabolic alterations are broadly observed across many cancer types, metabolic reprogramming is considered a hallmark of cancer. A metabolic alteration commonly seen in cancer cells is an increased demand for certain amino acids. Amino acids are involved in a wide range of...
Paper Details
Title
Pharmacologic approaches to amino acid depletion for cancer therapy
Published Date
Sep 17, 2021
Volume
61
Issue
2
Pages
127 - 152
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