Structural basis for small molecule targeting of Doublecortin Like Kinase 1 with DCLK1-IN-1
Volume: 4, Issue: 1
Published: Sep 20, 2021
Abstract
Doublecortin-like kinase 1 (DCLK1) is an understudied bi-functional kinase with a proven role in tumour growth and development. However, the presence of tissue-specific spliced DCLK1 isoforms with distinct biological functions have challenged the development of effective strategies to understand the role of DCLK1 in oncogenesis. Recently, DCLK1-IN-1 was reported as a highly selective DCLK1 inhibitor, a powerful tool to dissect DCLK1 biological...
Paper Details
Title
Structural basis for small molecule targeting of Doublecortin Like Kinase 1 with DCLK1-IN-1
Published Date
Sep 20, 2021
Volume
4
Issue
1
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