Molecular genetic evidence supporting diverse histogenic origins of germ cell tumors
Abstract
Germ cell tumors (GCTs) originate during the histogenesis of primordial germ cells to mature gametes. Previous studies identified five histogenic mechanisms in ovarian mature teratomas (type I: failure of meiosis I; type II: failure of meiosis II; type III: duplication of the genome of a mature gamete; type IV: no meiosis; and type V: fusion of two different ova), but those of other GCTs remain elusive. In this study, we analyzed 84 GCTs of...
Paper Details
Title
Molecular genetic evidence supporting diverse histogenic origins of germ cell tumors
Published Date
Oct 29, 2021
Journal
Volume
256
Issue
1
Pages
38 - 49
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History