Molecular basis of human ATM kinase inhibition

Volume: 28, Issue: 10, Pages: 789 - 798
Published: Sep 23, 2021
Abstract
Human checkpoint kinase ataxia telangiectasia-mutated (ATM) plays a key role in initiation of the DNA damage response following DNA double-strand breaks. ATM inhibition is a promising approach in cancer therapy, but, so far, detailed insights into the binding modes of known ATM inhibitors have been hampered due to the lack of high-resolution ATM structures. Using cryo-EM, we have determined the structure of human ATM to an overall resolution...
Paper Details
Title
Molecular basis of human ATM kinase inhibition
Published Date
Sep 23, 2021
Volume
28
Issue
10
Pages
789 - 798
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