Side Effect Patterns in a Crossover Trial of Statin, Placebo, and No Treatment

Most people who begin statins abandon them, most commonly because of side effects.The purpose of this study was to assess daily symptom scores on statin, placebo, and no treatment in participants who had abandoned statins.Participants received 12 1-month medication bottles, 4 containing atorvastatin 20 mg, 4 placebo, and 4 empty. We measured daily symptom intensity for each using an app (scale 1-100). We also measured the "nocebo" ratio: the...