IKKβ–NF-κB signaling in adult chondrocytes promotes the onset of age-related osteoarthritis in mice
Abstract
Canonical nuclear factor κB (NF-κB) signaling mediated by homo- and heterodimers of the NF-κB subunits p65 (RELA) and p50 (NFKB1) is associated with age-related pathologies and with disease progression in posttraumatic models of osteoarthritis (OA). Here, we established that NF-κB signaling in articular chondrocytes increased with age, concomitant with the onset of spontaneous OA in wild-type mice. Chondrocyte-specific expression of a...
Paper Details
Title
IKKβ–NF-κB signaling in adult chondrocytes promotes the onset of age-related osteoarthritis in mice
Published Date
Sep 21, 2021
Journal
Volume
14
Issue
701
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