O09 A double blind, randomised, placebo-controlled study to assess safety and tolerability of oral enterosorbent Carbalive (Yaq-001) in cirrhotic patients

Background

Yaq-001 is a non-absorbable, synthetic carbon with high adsorptive capacity for bacterial products including lipopolysaccharide (LPS) and pro-inflammatory cytokines. Studies in cirrhotic rats showed reduced endotoxemia, improvements in end-organ dysfunction and reduced sensitisation to LPS. The aims of this study were to evaluate the safety and tolerability of Yaq-001 in decompensated cirrhotic (DC) patients and characterise...