Sex in the Nucleus Accumbens: ΔFosB, Addiction, and Affective States.

Published on Oct 15, 2021in Biological Psychiatry13.382
· DOI :10.1016/J.BIOPSYCH.2021.08.002
Jean Lud Cadet98
Estimated H-index: 98
(NIDA: National Institute on Drug Abuse)
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Abstract
References10
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#9Jee Hyun Kim (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 28
Abstract null null Background null The onset and persistence of addiction phenotypes are, in part, mediated by transcriptional mechanisms in the brain that affect gene expression and, subsequently, neural circuitry. ΔFosB is a transcription factor that accumulates in the nucleus accumbens (NAc)—a brain region responsible for coordinating reward and motivation—after exposure to virtually every known rewarding substance, including cocaine and opioids. ΔFosB has also been shown to directly control ...
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#1Pratima MurthyH-Index: 22
#2Jayant MahadevanH-Index: 5
Last. Prabhat ChandH-Index: 14
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Purpose of reviewTo provide an update of treatment for substance use in patients with co-occurring substance use disorders (SUD) and mental health disorders (dual diagnosis) with a focus on both pharmacological and psychosocial interventions.Recent findingsA total of 1435 abstracts were identified,
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#1Jean Lud Cadet (NIDA: National Institute on Drug Abuse)H-Index: 98
#2Christie Brannock (NIDA: National Institute on Drug Abuse)H-Index: 13
Last. Richard S. Lee (Johns Hopkins University)H-Index: 40
view all 10 authors...
Epigenetic consequences of exposure to psychostimulants are substantial but the relationship of these changes to compulsive drug taking and abstinence is not clear. Here, we used a paradigm that helped to segregate rats that reduce or stop their methamphetamine (METH) intake (nonaddicted) from those that continue to take the drug compulsively (addicted) in the presence of footshocks. We used that model to investigate potential alterations in global DNA hydroxymethylation in the nucleus accumbens...
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#1Jean Lud Cadet (NIH: National Institutes of Health)H-Index: 98
Substance use disorders (SUDs) are highly prevalent. SUDs involve vicious cycles of binges followed by occasional periods of abstinence with recurrent relapses despite treatment and adverse medical and psychosocial consequences. There is convincing evidence that early and adult stressful life events are risks factors for the development of addiction and serve as cues that trigger relapses. Nevertheless, the fact that not all individuals who face traumatic events develop addiction to licit or ill...
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#1Jean Lud Cadet (NIDA: National Institute on Drug Abuse)H-Index: 98
#2Christie Brannock (NIDA: National Institute on Drug Abuse)H-Index: 13
Last. Irina N. Krasnova (NIDA: National Institute on Drug Abuse)H-Index: 30
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Methamphetamine use disorder is a chronic neuropsychiatric disorder characterized by recurrent binge episodes, intervals of abstinence, and relapses to drug use. Humans addicted to methamphetamine experience various degrees of cognitive deficits and other neurological abnormalities that complicate their activities of daily living and their participation in treatment programs. Importantly, models of methamphetamine addiction in rodents have shown that animals will readily learn to give themselves...
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#1R. Kathryn McHugh (Harvard University)H-Index: 38
#2Sara Wigderson (McLean Hospital)H-Index: 7
Last. Shelly F. Greenfield (Harvard University)H-Index: 43
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A significant number of women of reproductive age in the U.S. use addictive substances. In 2012 more than 50% reported current use of alcohol, 20% used tobacco products, and approximately 13% used other drugs. Among women, use of these substances is associated with a number of significant medical, psychiatric, and social consequences, and the course of illness may progress more rapidly in women than men. The lifetime prevalence of alcohol and drug use disorders in women is 19.5% and 7.1%, respec...
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#10Ramesh Chandra (UMB: University of Maryland, Baltimore)H-Index: 78
The transcription factor, ΔFosB, is robustly and persistently induced in striatum by several chronic stimuli, such as drugs of abuse, antipsychotic drugs, natural rewards, and stress. However, very few studies have examined the degree of ΔFosB induction in the two striatal medium spiny neuron (MSN) subtypes. We make use of fluorescent reporter BAC transgenic mice to evaluate induction of ΔFosB in dopamine receptor 1 (D1) enriched and dopamine receptor 2 (D2) enriched MSNs in ventral striatum, nu...
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#1Aldo Badiani (Sapienza University of Rome)H-Index: 36
#2David Belin (French Institute of Health and Medical Research)H-Index: 32
Last. Yavin Shaham (NIDA: National Institute on Drug Abuse)H-Index: 99
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The publication of the psychomotor stimulant theory of addiction in 1987 and the finding that addictive drugs increase dopamine concentrations in the rat mesolimbic system in 1988 have led to a predominance of psychobiological theories that consider addiction to opiates and addiction to psychostimulants as essentially identical phenomena. Indeed, current theories of addiction - hedonic allostasis, incentive sensitization, aberrant learning and frontostriatal dysfunction - all argue for a unitary...
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#1Eric J. Nestler (UTSW: University of Texas Southwestern Medical Center)H-Index: 197
#2Michel Barrot (UTSW: University of Texas Southwestern Medical Center)H-Index: 62
Last. David W. SelfH-Index: 57
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The longevity of some of the behavioral abnormalities that characterize drug addiction has suggested that regulation of neural gene expression may be involved in the process by which drugs of abuse cause a state of addiction. Increasing evidence suggests that the transcription factor ΔFosB represents one mechanism by which drugs of abuse produce relatively stable changes in the brain that contribute to the addiction phenotype. ΔFosB, a member of the Fos family of transcription factors, accumulat...
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#1Yusaku Nakabeppu (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 81
#2Daniel Nathans (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 71
Abstract Fos and Jun transcription factors are induced by a variety of extracellular signaling agents. We describe here an unusual member of the Fos family that is also induced, namely, a truncated form of FosB (ΔFosB) missing the C-terminal 101 amino acids of FosB. ΔFosB retains the dimerization and DNA-binding activities of FosB but has lost the ability in transfection assays to activate a promoter with an AP-1 site and to repress the c- fos promoter. Rather, ΔFosB inhibits gene activation by ...
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