Sex in the Nucleus Accumbens: ΔFosB, Addiction, and Affective States

SEE CORRESPONDING ARTICLE ON PAGE 540 Gene-Targeted, CREB-Mediated Induction of ΔFosB Controls Distinct Downstream Transcriptional Patterns Within D1 and D2 Medium Spiny NeuronsBiological PsychiatryVol. 90Issue 8PreviewThe onset and persistence of addiction phenotypes are, in part, mediated by transcriptional mechanisms in the brain that affect gene expression and, subsequently, neural circuitry. ΔFosB is a transcription factor that accumulates...