Internal medicine

Hemophagocytic lymphohistiocytosis

Disease

Biology

Antigen

Cytotoxic T cell

In vitro

Immunology

Perforin

T cell

Hemophagocytosis

Natural killer cell

Pancytopenia

Bone marrow

Biochemistry

Medicine

Immune system

Blood

HLH-like toxicities of CAR T cells (carHLH) occurring in those with CRS associated with higher CAR T-cell expansion and persistence. Recognition of carHLH as a CRS variant is needed to optimize treatment approaches and improve patient outcomes.

Characterization of HLH-like manifestations as a CRS variant in patients receiving CD22 CAR T cells