Predictable maternal separation confers adult stress resilience via the medial prefrontal cortex oxytocin signaling pathway in rats

Early-life stress is normally thought of as a major risk for psychiatric disorders, but many researchers have revealed that adversity early in life may enhance stress resilience later in life. Few studies have been performed in rodents to address the possibility that exposure to early-life stress may enhance stress resilience, and the underlying neural mechanisms are far from being understood. Here, we established a two-hit stress model in rats...