Total Synthesis and Antimicrobial Evaluation of Pagoamide A

Natural products are often the starting point for drug development and also the testing ground for synthetic methods. Herein we describe the total synthesis and antimicrobial evaluation of a marine natural product, pagoamide A, which is a macrocyclic depsipeptide with two backbone thiazole units and a dimethylated N -terminus. The two thiazole building blocks were synthesized from commercially available materials in four or fewer steps and...