The prognostic significance of pleomorphism in gastrointestinal stromal tumours

Gastrointestinal stromal tumours (GISTs) typically show uniform nuclear morphology, with spindle cell, epithelioid or mixed histology. Risk of progression in GIST is estimated based on anatomical site, tumour size and mitotic index. Pleomorphic GISTs are rare and have not been systematically investigated. We evaluated the prognostic significance of pleomorphism in GIST.In total, 108 of 2517 (4.3%) GISTs reviewed between 2000 and 2021 were...