Maternal B cell signaling orchestrates fetal development in mice
Abstract
B cell participation in early embryo/fetal development and the underlying molecular pathways have not been explored. To understand whether maternal B cell absence or impaired signaling interferes with placental and fetal growth, we paired CD19-deficient (CD19-/-) mice, females with B cell-specific MyD88 (BMyD88-/-) or IL10 (BIL10-/-) deficiency as well as wild-type and MyD88-/- controls on C57Bl/6 background with BALB/c males. Pregnancies were...
Paper Details
Title
Maternal B cell signaling orchestrates fetal development in mice
Published Date
Oct 26, 2021
Journal
Volume
149
Issue
8
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