Cytotoxic effect of carbohydrate derivatives of digitoxigenin involves modulation of plasma membrane Ca ²⁺ ‐ATPase

Cardiac glycosides, such as digoxin and digitoxin, are compounds that interact with Na + /K + ‐ATPase to induce anti‐neoplastic effects; however, these cardiac glycosides have narrow therapeutic index. Thus, semi‐synthetic analogs of digitoxin with modifications in the sugar moiety has been shown to be an interesting approach to obtain more selective and more effective analogs than the parent natural product. Therefore, the aim of this study was...