Intercrypt sentinel macrophages tune antibacterial NF-κB responses in gut epithelial cells via TNF

Volume: 218, Issue: 11
Published: Sep 16, 2021
Abstract
Intestinal epithelial cell (IEC) NF-κB signaling regulates the balance between mucosal homeostasis and inflammation. It is not fully understood which signals tune this balance and how bacterial exposure elicits the process. Pure LPS induces epithelial NF-κB activation in vivo. However, we found that in mice, IECs do not respond directly to LPS. Instead, tissue-resident lamina propria intercrypt macrophages sense LPS via TLR4 and rapidly secrete...
Paper Details
Title
Intercrypt sentinel macrophages tune antibacterial NF-κB responses in gut epithelial cells via TNF
Published Date
Sep 16, 2021
Volume
218
Issue
11
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