Break Away: FKBP12 sequestration as a target for increasing BMP activity

Bone morphogenetic protein (BMP) signaling contributes to acute kidney injury (AKI), a common disease without adequate treatment options. In this issue of Cell Chemical Biology, Larraufie, Gao and colleagues ( Larraufie et al., 2021 Larraufie M.-H. Gao X. Xia X. Devine P.J. Kallen J. Liu D. Michaud G. Harsch A. Savage N. Ding J. et al. Phenotypic screen identifies calcineurin-sparing FK506 analogs as BMP potentiators for treatment of acute...