Integrin Inhibitors in Inflammatory Bowel Disease: From Therapeutic Antibodies to Small-Molecule Drugs

See “PTG-100, an oral α4β7 antagonist peptide: preclinical development and phase 1 and 2a studies in ulcerative colitis” by Sandborn WJ, Mattheakis LC, Modi NB, et al, on page 1853. See “PTG-100, an oral α4β7 antagonist peptide: preclinical development and phase 1 and 2a studies in ulcerative colitis” by Sandborn WJ, Mattheakis LC, Modi NB, et al, on page 1853. Accumulation of leukocytes is the hallmark of inflammation; in inflammatory bowel...