Evolution and progression of Barrett’s oesophagus to oesophageal cancer
Abstract
Cancer cells are shaped through an evolutionary process of DNA mutation, cell selection and population expansion. Early steps in this process are driven by a set of mutated driver genes and structural alterations to the genome through copy number gains or losses. Oesophageal adenocarcinoma (EAC) and the pre-invasive tissue, Barrett's oesophagus (BE), provide an ideal example in which to observe and study this evolution. BE displays early genomic...
Paper Details
Title
Evolution and progression of Barrett’s oesophagus to oesophageal cancer
Published Date
Sep 20, 2021
Journal
Volume
21
Issue
11
Pages
731 - 741
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Notes
History