Development of bifunctional anti-PD-L1 antibody MMAE conjugate with cytotoxicity and immunostimulation
Abstract
In recent years, tumor immunotherapy, especially the combination of PD1/PD-L1 inhibitors and chemotherapy, has developed rapidly. However, the systemic side effects induced by chemotherapy remain a crucial problem that needs to be addressed. Antibody drug conjugates (ADCs) are exceptional target-specific prodrugs that greatly improve the therapeutic window of chemotherapy drugs. Therefore, designing PD-L1-targeting ADCs is an interesting...
Paper Details
Title
Development of bifunctional anti-PD-L1 antibody MMAE conjugate with cytotoxicity and immunostimulation
Published Date
Nov 1, 2021
Journal
Volume
116
Pages
105366 - 105366
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