Pdia4 regulates β-cell pathogenesis in diabetes: molecular mechanism and targeted therapy.

Volume: 13, Issue: 10, Pages: e11668 - e11668
Published: Oct 7, 2021
Abstract
Loss of β-cell number and function is a hallmark of diabetes. β-cell preservation is emerging as a promising strategy to treat and reverse diabetes. Here, we first found that Pdia4 was primarily expressed in β-cells. This expression was up-regulated in β-cells and blood of mice in response to excess nutrients. Ablation of Pdia4 alleviated diabetes as shown by reduced islet destruction, blood glucose and HbA1c, reactive oxygen species (ROS), and...
Paper Details
Title
Pdia4 regulates β-cell pathogenesis in diabetes: molecular mechanism and targeted therapy.
Published Date
Oct 7, 2021
Volume
13
Issue
10
Pages
e11668 - e11668
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