Identification of a PCSK9-LDLR disruptor peptide with in vivo function
Abstract
Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates plasma low-density lipoprotein cholesterol (LDL-C) levels by promoting hepatic LDL receptor (LDLR) degradation. Therapeutic antibodies that disrupt PCSK9-LDLR binding reduce LDL-C concentrations and cardiovascular disease risk. The epidermal growth factor precursor homology domain A (EGF-A) of the LDLR serves as a primary contact with PCSK9 via a flat interface, presenting a...
Paper Details
Title
Identification of a PCSK9-LDLR disruptor peptide with in vivo function
Published Date
Feb 1, 2022
Journal
Volume
29
Issue
2
Pages
249 - 258.e5
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Notes
History