Gene

Epidermis (zoology)

Pyoderma gangrenosum

Biology

Subclinical infection

Dermis

Dermatology

Computational biology

Immunology

Genetics

Anatomy

Inflammation

Medicine

Disease

Pathogenesis

Gene expression

Pathology

Journal of Investigative Dermatology

Pyoderma gangrenosum (PG) is characterized by painful ulcers typically affecting the lower extremities. PG pathogenesis and triggers are poorly understood (Ortega-Loayza et al., 2018). Treatments target systemic inflammation, but clinical response and outcomes remain unpredictable. Further investigations are necessary to understand PG pathobiology; however, little is known about gene expression in PG, including whether important changes localize to the dermis or epidermis and whether nonlesional skin from patients with PG shows subclinical signs of the disease.

Molecular and Cellular Characterization of Pyoderma Gangrenosum: Implications for the Use of Gene Expression