The triglyceride-glucose index is a more powerful surrogate marker for predicting the prevalence and incidence of type 2 diabetes mellitus than the homeostatic model assessment of insulin resistance.

Published on Oct 1, 2021in Diabetes Research and Clinical Practice5.602
· DOI :10.1016/J.DIABRES.2021.109042
Hye Min Park13
Estimated H-index: 13
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Abstract
Abstract null null Aims null Insulin resistance is an independent risk factor for developing type 2 diabetes. Therefore, this study compared the predictability of the triglyceride–glucose (TyG) index and the homeostatic model assessment of insulin resistance (HOMA-IR) for the prevalence and incidence of type 2 diabetes. null null null Methods null We analyzed data from 9730 adults aged 40–69 years at baseline and 7783 participants without diabetes who were followed up in the Korean Genome and Epidemiology Study survey. From 2001 to 2002 (baseline survey) to 2013–2014, this survey was conducted biennially (six follow-ups). The average follow-up period was 9.0 years. null null null Results null The TyG index showed better predictability for the prevalence of type 2 diabetes than HOMA-IR (TyG index: 0.784, HOMA-IR: 0.728, p  null null null Conclusions null The TyG index is superior to HOMA-IR for predicting type 2 diabetes. The TyG index could, therefore, be more useful for the early detection and prevention of type 2 diabetes.
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References42
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#1Xiao-Cong Liu (Academy of Medical Sciences, United Kingdom)H-Index: 2
#2Guodong He (Cardiovascular Institute of the South)H-Index: 5
Last. Yingqing Feng (Academy of Medical Sciences, United Kingdom)H-Index: 9
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Abstract Background: The triglyceride-glucose (TyG) index could serve as a convenient substitute of insulin resistance (IR), but epidemiological evidence on its relationship with the long-term risk of mortality is limited. Methods: Participants from the National Health and Nutrition Examination Survey during 1999–2014 were grouped according to TyG index (10). Cox regression was conducted to compute the hazard ratios (HRs) and 95% confidence interval (CI). Restricted cubic spline and piecewise li...
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#1Tai-Hua Chiu (KMU: Kaohsiung Medical University)H-Index: 2
#2Ya-Chin Huang (KMU: Kaohsiung Medical University)H-Index: 2
Last. Szu-Chia ChenH-Index: 23
view all 7 authors...
This study aimed to evaluate the performance of 11 obesity-related indices, including body mass index (BMI), waist circumference, waist-to-height ratio, waist-hip ratio, a body shape index, abdominal volume index, body adiposity index, body roundness index, conicity index, visceral adiposity index (VAI), and triglyceride glucose (TyG) index, in identifying metabolic syndrome (MetS) in adults. The information of 5000 participants was obtained from the Taiwan Biobank. Logistic regression analyses ...
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#1Alessandra da Silva (UFV: Universidade Federal de Viçosa)H-Index: 5
#2Ana Paula Silva Caldas (UFV: Universidade Federal de Viçosa)H-Index: 7
Last. Josefina Bressan (UFV: Universidade Federal de Viçosa)H-Index: 35
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Abstract Objective Our objective was to perform a systematic review and meta-analysis of cohort studies evaluating the triglyceride-glucose (TyG) index as a tool for type 2 diabetes (T2D) prediction in adults and older adults. Methods Studies were identified in PubMed, Cochrane, Scopus, and Lilacs. Studies with cohort design, which evaluated the T2D incidence through the hazard ratio (HR) or relative risk (RR) or odds ratio values were included. Were included both studies that evaluated the inci...
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#1Minglei Ma (Peking Union Medical College Hospital)H-Index: 4
#2Haibin Liu (Capital Medical University)H-Index: 3
Last. Yuxiu Li (Peking Union Medical College Hospital)H-Index: 11
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Previous studies on the effects of lipotoxicity and oxidative stress on islet beta cell function mainly focused on patients with diabetes, whereas studies on normal glucose tolerance (NGT) are few. The aim of this study was to explore the relationships among triglyceride (TG), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), oxidative stress indicators, insulin resistance, and beta cell function in populations with different glucose and lipid metabolism ...
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#1Teresa Vanessa Fiorentino (Magna Græcia University)H-Index: 21
#2Maria Adelaide Marini (University of Rome Tor Vergata)H-Index: 28
Last. Giorgio Sesti (Sapienza University of Rome)H-Index: 77
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Introduction Insulin resistance plays a crucial role in the pathogenesis of type 2 diabetes and cardiovascular disease. The triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio, visceral adiposity index (VAI), lipid accumulation product (LAP) and triglycerides × fasting glucose (TyG) index are surrogate measures of insulin sensitivity based on anthropometric and/or biochemical parameters routinely collected in clinical practice. Herein, we compared the relationships of these fou...
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#1Aya Kitae (Kyoto Prefectural University of Medicine)H-Index: 2
#2Yoshitaka Hashimoto (Kyoto Prefectural University of Medicine)H-Index: 18
Last. Michiaki Fukui (Kyoto Prefectural University of Medicine)H-Index: 47
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Background. The triglyceride and glucose index (TyG), defined as the product of triglycerides (TG) and fasting plasma glucose (FPG), is reported as a surrogate index for insulin resistance. Although a cross-sectional study revealed the association between the TyG-index and the prevalence of nonalcoholic fatty liver disease (NAFLD), few studies have investigated the association between the TyG-index and incident NAFLD. Here we investigated whether the TyG-index can be used to predict incident NAF...
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#1Mee-Ri Lee (SCH: Soonchunhyang University)H-Index: 3
#2Sung Min Jung (Inje University)H-Index: 3
Last. Yong Bae Kim (SCH: Soonchunhyang University)H-Index: 3
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AbstractThere are few existing studies that examine the association between muscle strength and cardiovascular disease (CVD) risk stratified by sex. Evaluation of the handgrip strength is a simple, quick, and inexpensive method to measure muscle strength. This study assessed the association of handg
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#1Eun Roh (KU: Korea University)H-Index: 12
#2Kyoung M. Kim (Seoul National University Bundang Hospital)H-Index: 1
Last. Soo Lim (Seoul National University Bundang Hospital)H-Index: 65
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AIM: To compare pancreatic volume and fat amount, and their associations with glucose homeostasis, in a Korean and a white population. MATERIALS AND METHODS: In 43 healthy Korean and 43 healthy white people, matched for age (±3 years) and body mass index (BMI; ±1 kg/m2 ), we measured pancreatic volume and fat amount in the pancreas and abdomen using computed tomography. Pancreatic β-cell function and insulin resistance were estimated according to biochemical characteristics and a 75-g oral gluco...
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#1Yun Jung Lee (Catholic University of Korea)H-Index: 2
#2SuJin Song (Hannam University)H-Index: 5
Last. YoonJu Song (Catholic University of Korea)H-Index: 25
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PURPOSE: Although an Asian diet is typically high in carbohydrate and low in fat, there has been a steady increase in the rate of cardiometabolic disease in Asian countries over the past decade. We evaluated food patterns of a high-carbohydrate diet and examined their associations with metabolic disease. MATERIALS AND METHODS: Using data from the 2013-2015 Korean National Health and Nutrition Examination Survey, we included a total of 13106 subjects aged 20 years or older in this study. Diet was...
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#1Serena Low (Khoo Teck Puat Hospital)H-Index: 11
#2Kay Chin Jonathon Khoo (Khoo Teck Puat Hospital)H-Index: 2
Last. Tack Keong Michael Wong (Khoo Teck Puat Hospital)H-Index: 2
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Abstract Aims Triglyceride-Glucose (TyG) is an emerging surrogate indicator of insulin resistance. We explored the role of TyG in development of Type 2 Diabetes Mellitus (T2DM) and elucidated the mechanism for the relationship. Methods 4109 subjects without baseline T2DM participated in a community screening programme in 2013–2016. TyG was calculated as Ln[fasting triglyceride level (mg/dl) × fasting plasma glucose (FPG) (mg/dl)/2]. Outcome was T2DM defined as FPG ≥ 7.0 mmol/l; current treatment...
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