Incipient citrus polymethoxylated flavone Tangeretin as anticancer drug candidate: Mechanistic insights, limitations and possible solutions

Tangeretin is one of the many polymethoxyflavones (PMFs) mostly found in fruits and fruit peels of citrus plants. In view of its importance as a nutraceutical it has received extensive scientific scrutiny with regards to its suspected diverse bioactivities including anti-oxidant, anti-diabetes, anti-inflammatory, neuroprotection, efflux pump inhibition, anti-microbial, and mitochondrial biogenesis just to mention but a few have been confirmed in...