Endothelial hyaluronan synthase 3 aggravates acute colitis in an experimental model of inflammatory bowel disease
Abstract
The association between hyaluronan (HA) accumulation and increased inflammation in the colon suggests that HA is a potential therapeutic target in inflammatory bowel disease (IBD). However, whether patients with IBD would benefit from interference with HA synthesis is unknown. Here, we used pharmacological and genetic approaches to investigate the impact of systemic and partial blockade of HA synthesis in the Dextran Sodium Sulfate (DSS)-induced...
Paper Details
Title
Endothelial hyaluronan synthase 3 aggravates acute colitis in an experimental model of inflammatory bowel disease
Published Date
Aug 1, 2021
Journal
Volume
102
Pages
20 - 36
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