Targeting ARID1A mutations in cancer
Abstract
Genes encoding SWI/SNF chromatin remodeling complex subunits are collectively mutated in approximately 20% of human cancers. ARID1A is a SWI/SNF subunit gene whose protein product binds DNA. ARID1A gene alterations result in loss of function. It is the most commonly mutated member of the SWI/SNF complex, being aberrant in ∼6% of cancers overall, including ovarian clear cell cancers (∼45% of patients) and uterine endometrioid cancers (∼37%)....
Paper Details
Title
Targeting ARID1A mutations in cancer
Published Date
Nov 1, 2021
Journal
Volume
100
Pages
102287 - 102287
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