Autoimmunity affecting the biliary tract fuels the immunosurveillance of cholangiocarcinoma

Volume: 218, Issue: 10
Published: Sep 8, 2021
Abstract
Cholangiocarcinoma (CCA) results from the malignant transformation of cholangiocytes. Primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC) are chronic diseases in which cholangiocytes are primarily damaged. Although PSC is an inflammatory condition predisposing to CCA, CCA is almost never found in the autoimmune context of PBC. Here, we hypothesized that PBC might favor CCA immunosurveillance. In preclinical murine models...
Paper Details
Title
Autoimmunity affecting the biliary tract fuels the immunosurveillance of cholangiocarcinoma
Published Date
Sep 8, 2021
Volume
218
Issue
10
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