Mechanistic dissection of dominant AIRE mutations in mouse models reveals AIRE autoregulation

Volume: 218, Issue: 11
Published: Sep 3, 2021
Abstract
The autoimmune regulator (AIRE) is essential for the establishment of central tolerance and prevention of autoimmunity. Interestingly, different AIRE mutations cause autoimmunity in either recessive or dominant-negative manners. Using engineered mouse models, we establish that some monoallelic mutants, including C311Y and C446G, cause breakdown of central tolerance. By using RNAseq, ATACseq, ChIPseq, and protein analyses, we dissect the...
Paper Details
Title
Mechanistic dissection of dominant AIRE mutations in mouse models reveals AIRE autoregulation
Published Date
Sep 3, 2021
Volume
218
Issue
11
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