Gene

Golgi apparatus

Peroxisome

Pathology

Endoplasmic reticulum

Organelle

Apoptosis

Neurodegeneration

Disease

Mitochondrion

Programmed cell death

Biochemistry

Medicine

Biology

Cell biology

Cell Death and Differentiation

Ferroptosis, a cell death modality characterized by iron-dependent lipid peroxidation, is involved in the development of multiple pathological conditions, including ischemic tissue damage, infection, neurodegeneration, and cancer. The cellular machinery responsible for the execution of ferroptosis integrates multiple pro-survival or pro-death signals from subcellular organelles and then ‘decides’ whether to engage the lethal process or not. Here, we outline the evidence implicating different organelles (including mitochondria, lysosomes, endoplasmic reticulum, lipid droplets, peroxisomes, Golgi apparatus, and nucleus) in the ignition or avoidance of ferroptosis, while emphasizing their potential relevance for human disease and their targetability for pharmacological interventions.

Organelle-specific regulation of ferroptosis