Peroxisome

Neurodegeneration

Biochemistry

Disease

Biology

Gene

Endoplasmic reticulum

Apoptosis

Programmed cell death

Cell biology

Pathology

Organelle

Mitochondrion

Golgi apparatus

Medicine

Cell Death and Differentiation

Ferroptosis, a cell death modality characterized by iron-dependent lipid peroxidation, is involved in the development of multiple pathological conditions, including ischemic tissue damage, infection, neurodegeneration, and cancer. The cellular machinery responsible for the execution of ferroptosis integrates multiple pro-survival or pro-death signals from subcellular organelles and then ‘decides’ whether to engage the lethal process or not. Here, we outline the evidence implicating different organelles (including mitochondria, lysosomes, endoplasmic reticulum, lipid droplets, peroxisomes, Golgi apparatus, and nucleus) in the ignition or avoidance of ferroptosis, while emphasizing their potential relevance for human disease and their targetability for pharmacological interventions.

Organelle-specific regulation of ferroptosis