Biopsy-proven lymphocytic myocarditis following first mRNA COVID-19 vaccination in a 40-year-old male: case report.

Published on Sep 6, 2021in Clinical Research in Cardiology5.46
· DOI :10.1007/S00392-021-01936-6
Peter Ehrlich2
Estimated H-index: 2
(Saarland University),
Karin Klingel78
Estimated H-index: 78
+ 4 AuthorsMichael Kindermann22
Estimated H-index: 22
(Saarland University)
#1Carolyn RosnerH-Index: 4
#2Leonard GenoveseH-Index: 4
Last. Abbas EmaminiaH-Index: 1
view all 20 authors...
#1Kathryn F. Larson (Mayo Clinic)H-Index: 7
#2Enrico AmmiratiH-Index: 32
Last. Cristina CavalottiH-Index: 2
view all 16 authors...
#10Norbert Hubner (MDC: Max Delbrück Center for Molecular Medicine)H-Index: 81
Inflammatory cardiomyopathy, characterized by inflammatory cell infiltration into the myocardium and a high risk of deteriorating cardiac function, has a heterogeneous aetiology. Inflammatory cardiomyopathy is predominantly mediated by viral infection, but can also be induced by bacterial, protozoal or fungal infections as well as a wide variety of toxic substances and drugs and systemic immune-mediated diseases. Despite extensive research, inflammatory cardiomyopathy complicated by left ventric...
#1Georgios Georgiopoulos ('KCL': King's College London)H-Index: 24
#2Stefano Figliozzi ('KCL': King's College London)H-Index: 2
Last. Tevfik F Ismail ('KCL': King's College London)H-Index: 24
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Background Patients with acute myocarditis (AM) are at increased risk of adverse cardiac events after the index episode. Late gadolinium enhancement (LGE) detected by cardiovascular magnetic resonance in patients with AM plays an important diagnostic role, but its prognostic significance remains unresolved. This systematic review and meta-analysis sought to assess the prognostic implications of cardiovascular magnetic resonance-derived LGE in patients with AM. Methods Data search was conducted f...
#1Darja Kanduc (University of Bari)H-Index: 29
Aim: To define the autoimmune potential of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. Methods: Experimentally validated epitopes cataloged at the Immune Epitope DataBase (IEDB) and present in SARS-CoV-2 were analyzed for peptide sharing with the human proteome. Results: Immunoreactive epitopes present in SARS-CoV-2 were mostly composed of peptide sequences present in human proteins that—when altered, mutated, deficient or, however, improperly functioning—may associat...
#1Vanessa M. Ferreira (John Radcliffe Hospital)H-Index: 22
#2Jeanette Schulz-Menger (Charité)H-Index: 68
Last. Matthias G. FriedrichH-Index: 64
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Abstract This JACC Scientific Expert Panel provides consensus recommendations for an update of the cardiovascular magnetic resonance (CMR) diagnostic criteria for myocardial inflammation in patients with suspected acute or active myocardial inflammation (Lake Louise Criteria) that include options to use parametric mapping techniques. While each parameter may indicate myocardial inflammation, the authors propose that CMR provides strong evidence for myocardial inflammation, with increasing specif...
Background— The objective of this study was to identify the prognostic indicators in patients with suspected myocarditis who underwent endomyocardial biopsy. Methods and Results— Between 1994 and 2007, 181 consecutive patients (age, 42±15 years) with clinically suspected viral myocarditis were enrolled and followed up for a mean of 59±42 months. Endomyocardial biopsies were studied for inflammation with histological (Dallas) and immunohistological criteria. Virus genome was detected by polymeras...
#1Joseph G. Murphy (Mayo Clinic)H-Index: 30
#2R. Scott Wright (Mayo Clinic)H-Index: 55
Last. Leslie T. Cooper (Mayo Clinic)H-Index: 77
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Summary Smallpox is an eradicated viral disease that has re-emerged as a potential bioterrorism threat. Smallpox vaccination was historically the most effective defence measure against wild smallpox virus. The risk of myopericarditis after vaccination might limit this option. We report a case of biopsy-proven eosinophilic-lymphocytic myocarditis diagnosed in vivo with histological evidence for eosinophil-mediated cardiac myocyte necrosis shortly after smallpox vaccination. Furthermore, we report...
Cited By0
#1Nicholas G. Kounis (University of Patras)H-Index: 26
#2Ioanna Koniari (University Hospital of South Manchester NHS Foundation Trust)H-Index: 15
Last. Grigorios Tsigkas (University of Patras)H-Index: 19
view all 5 authors...
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