Role of 53BP1 in end protection and DNA synthesis at DNA breaks
Volume: 35, Issue: 19-20, Pages: 1356 - 1367
Published: Sep 9, 2021
Abstract
Double-strand break (DSB) repair choice is greatly influenced by the initial processing of DNA ends. 53BP1 limits the formation of recombinogenic single-strand DNA (ssDNA) in BRCA1-deficient cells, leading to defects in homologous recombination (HR). However, the exact mechanisms by which 53BP1 inhibits DSB resection remain unclear. Previous studies have identified two potential pathways: protection against DNA2/EXO1 exonucleases presumably...
Paper Details
Title
Role of 53BP1 in end protection and DNA synthesis at DNA breaks
Published Date
Sep 9, 2021
Volume
35
Issue
19-20
Pages
1356 - 1367
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