Imaging of Cancer γ-Secretase Activity Using an Inhibitor-Based PET Probe.
Abstract
Purpose: null Abnormal Notch signaling promotes cancer cell growth and tumor progression in various cancers. Targeting γ-secretase, a pivotal regulator in the Notch pathway, has yielded numerous γ-secretase inhibitors (GSIs) for clinical investigation in the last 2 decades. However, GSIs have demonstrated minimal success in clinical trials in part due to the lack of specific and precise tools to assess γ-secretase activity and its inhibition in...
Paper Details
Title
Imaging of Cancer γ-Secretase Activity Using an Inhibitor-Based PET Probe.
Published Date
Nov 15, 2021
Journal
Volume
27
Issue
22
Pages
6145 - 6155
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Notes
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