Large Pediatric Randomized Clinical Trials in ClinicalTrials.gov

Large, randomized controlled trials (RCTs) are essential in answering pivotal questions in child health.We created a bird's eye view of all large, noncluster, nonvaccine pediatric RCTs with ≥1000 participants registered in ClinicalTrials.gov (last search January 9, 2020). We analyzed the funding sources, countries, outcomes, publication status, and correlation with the pediatric global burden of disease (GBD) for eligible trials.We identified...