Carrier-free micellar CpG interacting with cell membrane for enhanced immunological treatment of HIV-1
Abstract
Unmethylated CpG motifs activate toll-like receptor 9 (TLR9), leading to sequence- and species-specific immune stimulation. Here, we engineered a CpG oligodeoxyribonucleotide (ODN) with multiple hydrophobic moieties, so-called lipid-modified uracil, which resulted in a facile micelle formation of the stimulant. The self-assembled CpG nanostructure (U4CpG) containing the ODN 2216 sequence was characterized by various spectroscopic and microscopic...
Paper Details
Title
Carrier-free micellar CpG interacting with cell membrane for enhanced immunological treatment of HIV-1
Published Date
Oct 1, 2021
Journal
Volume
277
Pages
121081 - 121081
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History