RET Inhibitors in Non-Small-Cell Lung Cancer
Abstract
RET rearrangements are observed in 1–2% of non-small-cell lung cancer (NSCLC) patients and result in the constitutive activation of downstream pathways normally implied in cell proliferation, growth, differentiation and survival. In NSCLC patients, RET rearrangements have been associated with a history of non-smoking, a higher rate of brain metastasis at initial diagnosis and a low immune infiltrate. Traditionally, RET fusions are considered...
Paper Details
Title
RET Inhibitors in Non-Small-Cell Lung Cancer
Published Date
Sep 1, 2021
Journal
Volume
13
Issue
17
Pages
4415 - 4415
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