Microtubules in insulin action: what’s on the tube?

The work on microtubules (MT) and insulin can be thought of as one huge mystery novel, impossible to understand by reading a page or perhaps just one chapter; only after finishing the entire saga does a clear picture emerge. MT involvement in the acute insulin response that coordinates glucose transporter 4 (GLUT4) arrival at the plasma membrane (PM) is controversial, largely in part due to experiments with MT-depolymerizing agents. This review...