Nuclear IMPDH Filaments in Human Gliomas

Volume: 80, Issue: 10, Pages: 944 - 954
Published: Sep 8, 2021
Abstract
The analysis of nuclear morphology plays an important role in glioma diagnosis and grading. We previously described intranuclear rods (rods) labeled with the SDL.3D10 monoclonal antibody against class III beta-tubulin (TUBB3) in human ependymomas. In a cohort of adult diffuse gliomas, we identified nuclear rods in 71.1% of IDH mutant lower-grade gliomas and 13.7% of IDH wild-type glioblastomas (GBMs). The presence of nuclear rods was associated...
Paper Details
Title
Nuclear IMPDH Filaments in Human Gliomas
Published Date
Sep 8, 2021
Journal
Volume
80
Issue
10
Pages
944 - 954
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