Natural killer cells and dendritic epidermal γδ T cells orchestrate type 1 conventional DC spatiotemporal repositioning toward CD8+ T cells

Volume: 24, Issue: 9, Pages: 103059 - 103059
Published: Sep 1, 2021
Abstract
•Upon viral infection in the spleen, NK cells clusterize with cDC1 in the marginal zone•This XCL1/XCR1-dependent interaction allows mutual delivery of activating signals•NK cell GM-CSF directs cDC1 migration to T cell zone boosting CD8+ T cell priming•In the skin, DETCs contact cDC1 via XCL1/XCR1 to promote antiviral CD8+ T cell priming Successful immune responses rely on a regulated delivery of the right signals to the right cells at the right...
Paper Details
Title
Natural killer cells and dendritic epidermal γδ T cells orchestrate type 1 conventional DC spatiotemporal repositioning toward CD8+ T cells
Published Date
Sep 1, 2021
Journal
Volume
24
Issue
9
Pages
103059 - 103059
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